CCDC138

Across TCGA cell cohorts, CCDC138 mutation is significantly associated with the mutation status of many other genes, with 1,378 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC138-associated genes across cancer lineages are TGFBR3, KAT8, and SCAP. Each is linked with CCDC138 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC138-to-partner and partner-to-CCDC138 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGFBR3 grouped by CCDC138-low versus CCDC138-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC138→partner) and Y-score (partner→CCDC138) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TGFBR3 →	+5.824	+5.824	.002	.002	1	2
SKIN	KAT8 →	+4.239	+5.053	.007	.007	1	2
SKIN	SCAP →	+4.824	+5.392	.004	.004	1	2
SKIN	THAP6 →	+4.824	+5.392	.004	.004	1	2
SKIN	GLDN →	+4.824	+5.392	.004	.004	1	2
STOMACH	JAG1 →	+4.000	+4.700	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,378 associations by consensus.

TGFBR3 by CCDC138 expression — SKIN

Explore this box plot interactively →