Across TCGA pan-cancer cohorts, CCDC137 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CCDC137’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CCDC137 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CCDC137 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
HNSC, KIRP, and COAD are the cancer types where CCDC137 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC137 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.