CCDC13

Across TCGA patient cohorts, CCDC13 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC13-associated genes across cancer lineages are STAT3_pY705, 4E-BP1_pS65, and EGFR_pY1068. Each is linked with CCDC13 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC13-to-partner and partner-to-CCDC13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by CCDC13-low versus CCDC13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC13→partner) and Y-score (partner→CCDC13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.362	-2.212	<.001	.010	3	3
SKCM	4E-BP1_pS65 →	+0.315	+3.182	.001	.009	3	2
UCEC	EGFR_pY1068 →	-0.261	-2.087	.006	.005	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.386	-2.000	.025	.030	3	2
UCEC	p70-S6K →	+0.165	+2.114	.025	.003	3	2
UCEC	Shc_pY317 →	-0.171	-2.087	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

STAT3_pY705 by CCDC13 expression — UCEC

Explore this box plot interactively →