CCDC126

Across TCGA patient cohorts, CCDC126 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC126-associated genes across cancer lineages are Notch1, Tuberin, and MEK1. Each is linked with CCDC126 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC126-to-partner and partner-to-CCDC126 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CCDC126-low versus CCDC126-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC126→partner) and Y-score (partner→CCDC126) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.163	+3.009	.026	.019	3	1
UCEC	Tuberin →	+0.337	+3.009	.016	.019	3	1
UCEC	MEK1 →	+0.505	+3.321	.008	.010	1	1
UCEC	ASNS →	+0.657	+3.321	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Notch1 by CCDC126 expression — UCEC

Explore this box plot interactively →