CCDC122

Across TCGA pan-cancer cohorts, CCDC122 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CCDC122 data layer compared with 3 for mutation status.

The strongest signal is observed in brain lower grade glioma (LGG), where higher CCDC122 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CCDC122 expression acts as an unfavorable survival marker, although some lineages such as KIRP and COAD show a favorable association.

LGG, KIRP, and COAD are the cancer types where CCDC122 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.733	0.883	<.001	51	view →
KIRP	DFS	Median	II,III,IV	0.842	0.168	.001	48	view →
COAD	OS	Median	IV	0.711	0.353	.010	27	view →
PAAD	DFS	Median	II,III,IV	0.357	0.252	.012	25	view →
KIRC	OS	Tertile	All	0.850	0.764	.011	22	view →
UVM	OS	Quartile	III,IV	0.336	0.909	.011	22	view →
THCA	DFS	Quartile	II,III,IV	0.804	1.000	.002	17	view →
BLCA	OS	Median	II,III,IV	0.773	0.660	.010	16	view →
UCEC	DFS	Tertile	All	0.938	0.862	.006	14	view →
OV	DFS	Tertile	II,III,IV	0.145	0.230	.022	12	view →
ACC	DFS	Quartile	II,III,IV	0.128	0.673	.009	10	view →
MESO	DFS	Median	II,III,IV	0.303	0.597	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CCDC122–LGG (OS)

Open the LGG breakdown →