CCDC121

Across TCGA patient cohorts, CCDC121 mutation is significantly associated with the RNA expression of many other genes, with 3,218 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC121-associated genes across cancer lineages are MIR548I3, MTND4P33, and SRIP1. Each is linked with CCDC121 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC121-to-partner and partner-to-CCDC121 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548I3 grouped by CCDC121-low versus CCDC121-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC121→partner) and Y-score (partner→CCDC121) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	MIR548I3 →	+0.379	+7.977	<.001	.007	3	3
BLCA	MTND4P33 →	+0.070	+5.899	<.001	.002	3	2
SKCM	SRIP1 →	+0.189	+6.080	<.001	.002	3	2
UCEC	MIR6803 →	+0.097	+3.777	<.001	.007	3	2
UCEC	RNA5SP418 →	+0.737	+1.785	<.001	.003	3	2
LUSC	CENPVL1 →	+0.061	+6.309	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,218 associations by consensus.

MIR548I3 by CCDC121 expression — LGG

Explore this box plot interactively →