CCDC121

Across TCGA patient cohorts, CCDC121 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC121-associated genes across cancer lineages are 14-3-3_beta, eEF2, and eIF4G. Each is linked with CCDC121 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC121-to-partner and partner-to-CCDC121 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CCDC121-low versus CCDC121-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC121→partner) and Y-score (partner→CCDC121) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.120	-3.780	<.001	<.001	3	1
UCEC	eEF2 →	+0.358	+3.459	.004	.005	3	1
UCEC	eIF4G →	+0.237	+2.000	.030	.030	3	1
UCEC	A-Raf_pS299 →	-0.182	-3.807	<.001	<.001	3	1
UCEC	ERK2 →	+0.188	+2.115	.005	.016	3	1
UCEC	Gab2 →	+0.293	+1.362	.020	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

14-3-3_beta by CCDC121 expression — UCEC

Explore this box plot interactively →