CCDC117

Across TCGA patient cohorts, CCDC117 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC117-associated genes across cancer lineages are Notch1, eIF4E, and ERK2. Each is linked with CCDC117 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC117-to-partner and partner-to-CCDC117 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CCDC117-low versus CCDC117-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC117→partner) and Y-score (partner→CCDC117) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.183	+3.087	.001	<.001	3	2
UCEC	eIF4E →	+0.219	+3.472	.009	.002	3	1
UCEC	ERK2 →	+0.201	+1.906	.009	.016	3	1
UCEC	FASN →	+0.451	+1.906	.004	.016	3	1
UCEC	FoxM1 →	+0.372	+3.087	<.001	<.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.189	-2.896	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Notch1 by CCDC117 expression — UCEC

Explore this box plot interactively →