CCDC112

Across TCGA patient cohorts, CCDC112 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC112-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and Acetyl-a-Tubulin-Lys40. Each is linked with CCDC112 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC112-to-partner and partner-to-CCDC112 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CCDC112-low versus CCDC112-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC112→partner) and Y-score (partner→CCDC112) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.217	-2.584	.024	.010	3	1
UCEC	A-Raf_pS299 →	-0.124	-2.000	.006	.030	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.383	+1.884	.049	.030	3	1
UCEC	JNK2 →	+0.277	+1.901	<.001	.028	3	1
UCEC	MEK1 →	+0.615	+3.247	<.001	<.001	3	1
UCEC	Notch1 →	+0.175	+2.584	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by CCDC112 expression — UCEC

Explore this box plot interactively →