CCDC105

Across TCGA patient cohorts, CCDC105 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC105-associated genes across cancer lineages are mTOR_pS2448, PEA-15, and CD49b. Each is linked with CCDC105 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC105-to-partner and partner-to-CCDC105 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by CCDC105-low versus CCDC105-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC105→partner) and Y-score (partner→CCDC105) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.217	-2.680	<.001	.006	3	2
SKCM	PEA-15 →	+0.214	+3.321	<.001	.009	3	1
SKCM	CD49b →	+0.197	+1.602	.031	.021	3	1
UCEC	eEF2 →	+0.366	+2.999	.015	.035	3	1
UCEC	EGFR_pY1068 →	-0.274	-3.459	.010	.005	3	1
UCEC	eIF4E →	+0.256	+4.000	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

mTOR_pS2448 by CCDC105 expression — UCEC

Explore this box plot interactively →