CCAR2

Across TCGA patient cohorts, CCAR2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCAR2-associated genes across cancer lineages are Akt_pT308, P-Cadherin, and Rad50. Each is linked with CCAR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCAR2-to-partner and partner-to-CCAR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by CCAR2-low versus CCAR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCAR2→partner) and Y-score (partner→CCAR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.437	+2.000	.023	.029	3	2
UCEC	P-Cadherin →	-0.125	-2.415	.004	.002	3	2
UCEC	Rad50 →	-0.222	-2.536	.002	<.001	3	2
UCEC	Annexin-1 →	+0.333	+1.720	.039	.025	3	2
UCEC	Caspase-7-cleavedD198 →	+0.455	+2.000	.012	.029	3	2
UCEC	eIF4E →	+0.198	+4.013	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Akt_pT308 by CCAR2 expression — UCEC

Explore this box plot interactively →