CC2D1B

Across TCGA pan-cancer cohorts, CC2D1B mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CC2D1B’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where CC2D1B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CC2D1B is over-expressed in tumor, although a few such as LSCC and HNSC show the opposite, repressed pattern.

LSCC, HNSC, and LUAD are the cancer types where CC2D1B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CC2D1B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	−0.315	<.001	8	view →
HNSC	Male	IV	−0.249	<.001	8	view →
LUAD	Male	All	−0.159	<.001	6	view →
COAD	Male	All	−0.124	.004	6	view →
PDAC	All	All	+0.120	.008	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CC2D1B–LSCC

Open the LSCC breakdown →