Across TCGA pan-cancer cohorts, CBY1P1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of CBY1P1’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where CBY1P1 RNA is repressed in tumor relative to normal tissue. In most cancer types CBY1P1 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.
COAD and THCA are the cancer types where CBY1P1 tumor–normal differential expression is most reproducible.