CBY1

Across TCGA pan-cancer cohorts, CBY1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CBY1 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CBY1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CBY1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where CBY1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.293	1.000	.006	18	view →
LSCC	DFS	Median	II,III,IV	0.857	0.988	.010	14	view →
PDAC	DFS	Tertile	All	0.900	0.240	.024	9	view →
GBM	OS	Median	All	0.451	0.872	.022	3	view →
UCEC	OS	Median	All	0.850	0.978	.021	2	view →
LUAD	DFS	Median	All	0.698	0.467	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CBY1–HNSC (DFS)

Open the HNSC breakdown →