CBX8

Across TCGA pan-cancer cohorts, CBX8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CBX8 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CBX8 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CBX8 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where CBX8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.983	0.481	.002	20	view →
PDAC	DFS	Median	III,IV	0.364	0.692	.017	9	view →
HNSC	DFS	Tertile	III,IV	0.911	1.000	.028	3	view →
UCEC	OS	Median	All	0.917	0.981	.040	2	view →
LSCC	OS	Quartile	III,IV	0.651	0.970	.047	2	view →
GBM	OS	Quartile	All	0.720	0.437	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CBX8–LUAD (OS)

Open the LUAD breakdown →