CBX8

Across TCGA patient cohorts, CBX8 mutation is significantly associated with the RNA expression of many other genes, with 880 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBX8-associated genes across cancer lineages are CD274, VPS18, and KCTD9. Each is linked with CBX8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CBX8-to-partner and partner-to-CBX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD274 grouped by CBX8-low versus CBX8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX8→partner) and Y-score (partner→CBX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD274 →	+0.644	+3.329	<.001	.005	3	3
UCEC	VPS18 →	+0.550	+4.000	.001	<.001	3	2
UCEC	KCTD9 →	+0.577	+3.202	.006	.009	3	2
UCEC	CAMTA2 →	+0.373	+3.500	.008	.002	3	2
UCEC	CORO1C →	+0.583	+3.617	.001	.001	3	2
UCEC	DHDDS →	+0.495	+2.917	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 880 associations by consensus.

CD274 by CBX8 expression — UCEC

Explore this box plot interactively →