CBX8

Across TCGA patient cohorts, CBX8 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBX8-associated genes across cancer lineages are p62 Lck ligand, STAT5a, and Caspase-7-cleavedD198. Each is linked with CBX8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBX8-to-partner and partner-to-CBX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CBX8-low versus CBX8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX8→partner) and Y-score (partner→CBX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.545	+3.906	<.001	<.001	3	2
UCEC	STAT5a →	+0.440	+2.321	.011	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.896	+2.479	<.001	.010	3	2
SKCM	Cyclin-B1 →	+0.730	+2.820	.003	.035	2	2
UCEC	14-3-3_beta →	-0.093	-2.973	.033	.035	3	1
UCEC	eIF4G →	+0.289	+2.999	.032	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

p62 Lck ligand by CBX8 expression — UCEC

Explore this box plot interactively →