CBX8

Across TCGA cell cohorts, CBX8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,573 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CBX8-associated GO terms across cancer lineages are Copper ion export, Regulation of DNA repair, and Positive regulation of gene expression, epigenetic. Each is linked with CBX8 in more than 12 cancer types. Because this analysis shows association rather than direction, both CBX8-to-partner and partner-to-CBX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Copper ion export grouped by CBX8-low versus CBX8-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX8→partner) and Y-score (partner→CBX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Copper ion export →	-0.184	-0.577	<.001	<.001	3	13
BONE	Regulation of DNA repair →	+0.101	+1.333	<.001	<.001	3	13
BONE	Positive regulation of gene expression, epigenetic →	+0.073	+1.072	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Epigenetic regulation of gene expression →	+0.080	+0.851	<.001	.002	3	12
LIVER	Positive regulation of DNA repair →	+0.087	+0.766	<.001	.003	3	12
SKIN	Promoter clearance during DNA-templated transcription →	+0.100	+0.814	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,573 associations by consensus.

Copper ion export by CBX8 expression — OESOPHAGUS

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