CBX8

Across TCGA cell cohorts, CBX8 mutation is significantly associated with the RNA expression of many other genes, with 81 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CBX8-associated genes across cancer lineages are TACR3, PRND, and TEX43. Each is linked with CBX8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBX8-to-partner and partner-to-CBX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TACR3 grouped by CBX8-low versus CBX8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX8→partner) and Y-score (partner→CBX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TACR3 →	+0.034	+4.060	<.001	.003	3	1
BLOOD_Leukemia	PRND →	+0.011	+5.289	<.001	<.001	3	1
BLOOD_Leukemia	TEX43 →	+0.084	+4.384	<.001	.006	3	1
BLOOD_Leukemia	CCT8L2 →	+0.015	+3.874	<.001	.005	3	1
BLOOD_Leukemia	IQCF6 →	+0.558	+3.769	<.001	.008	3	1
BLOOD_Leukemia	NTF4 →	+0.113	+3.786	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

TACR3 by CBX8 expression — BLOOD_Leukemia

Explore this box plot interactively →