CBX3

Across TCGA patient cohorts, CBX3 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBX3-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PKC-b-II_pS660, and EGFR_pY1173. Each is linked with CBX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBX3-to-partner and partner-to-CBX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by CBX3-low versus CBX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX3→partner) and Y-score (partner→CBX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.546	-3.156	.027	.020	3	1
UCEC	PKC-b-II_pS660 →	-0.300	-3.169	.048	.020	3	1
UCEC	EGFR_pY1173 →	+0.122	+3.196	.005	.010	2	1
UCEC	p62 Lck ligand →	+0.415	+3.009	.020	.019	2	1
UCEC	Ku80 →	+0.343	+3.183	.008	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p38-MAPK_pT180_Y182 by CBX3 expression — UCEC

Explore this box plot interactively →