CBX3

Across TCGA cell cohorts, CBX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,214 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CBX3-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgG isotypes, Mitotic sister chromatid cohesion, and Regulation of G2/M transition of mitotic cell cycle. Each is linked with CBX3 in more than 15 cancer types. Because this analysis shows association rather than direction, both CBX3-to-partner and partner-to-CBX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgG isotypes grouped by CBX3-low versus CBX3-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX3→partner) and Y-score (partner→CBX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Positive regulation of isotype switching to IgG isotypes →	+0.158	+1.074	<.001	<.001	3	16
BLOOD_Myeloma	Mitotic sister chromatid cohesion →	+0.136	+1.465	<.001	<.001	3	16
OESOPHAGUS	Regulation of G2/M transition of mitotic cell cycle →	+0.110	+0.828	<.001	.001	3	15
BONE	Regulation of cell cycle G2/M phase transition →	+0.087	+0.723	<.001	<.001	3	15
BONE	Metaphase chromosome alignment →	+0.126	+0.636	.002	<.001	3	15
OESOPHAGUS	Negative regulation of nuclear division →	+0.174	+0.866	.003	<.001	2	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,214 associations by consensus.

Positive regulation of isotype switching to IgG isotypes by CBX3 expression — BLOOD_Lymphoma

Explore this box plot interactively →