CBX2

Across TCGA patient cohorts, CBX2 mutation is significantly associated with the RNA expression of many other genes, with 1,629 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBX2-associated genes across cancer lineages are SNRPCP8, MIER3, and NF1P6. Each is linked with CBX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CBX2-to-partner and partner-to-CBX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPCP8 grouped by CBX2-low versus CBX2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX2→partner) and Y-score (partner→CBX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SNRPCP8 →	+0.223	+3.587	<.001	.002	3	3
UCEC	MIER3 →	+0.463	+2.254	.006	.005	3	3
SKCM	NF1P6 →	+0.445	+2.885	<.001	.008	3	2
UCEC	ZNF595 →	+0.437	+2.454	.009	.001	3	2
UCEC	ZNHIT3 →	+0.443	+2.930	.001	<.001	3	2
UCEC	TMEM269 →	+0.269	+4.241	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,629 associations by consensus.

SNRPCP8 by CBX2 expression — LUSC

Explore this box plot interactively →