CBX2

Across TCGA patient cohorts, CBX2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBX2-associated genes across cancer lineages are MEK1, MSH6, and Annexin-1. Each is linked with CBX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBX2-to-partner and partner-to-CBX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CBX2-low versus CBX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX2→partner) and Y-score (partner→CBX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.289	+2.115	.039	.017	3	2
UCEC	MSH6 →	-0.374	-2.459	.003	.018	3	2
UCEC	Annexin-1 →	+0.650	+2.807	.001	.002	3	2
UCEC	TIGAR →	+0.117	+1.704	.045	.013	3	2
UCEC	FOXO3a →	-0.125	-3.877	.001	<.001	3	1
UCEC	GATA3 →	-0.146	-2.301	.044	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MEK1 by CBX2 expression — UCEC

Explore this box plot interactively →