CBX2

Across TCGA cell cohorts, CBX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,686 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CBX2-associated GO terms across cancer lineages are Regulation of nucleotide-excision repair, Epigenetic regulation of gene expression, and DNA strand elongation involved in DNA replication. Each is linked with CBX2 in more than 16 cancer types. Because this analysis shows association rather than direction, both CBX2-to-partner and partner-to-CBX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nucleotide-excision repair grouped by CBX2-low versus CBX2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX2→partner) and Y-score (partner→CBX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of nucleotide-excision repair →	+0.153	+1.716	<.001	<.001	3	17
BONE	Epigenetic regulation of gene expression →	+0.069	+1.823	<.001	<.001	3	17
PANCREAS	DNA strand elongation involved in DNA replication →	+0.197	+1.606	<.001	<.001	3	16
BONE	DNA replication-dependent chromatin assembly →	+0.214	+2.586	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Transcription initiation at RNA polymerase II promoter →	+0.078	+1.445	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Heterochromatin organization →	+0.063	+2.078	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,686 associations by consensus.

Regulation of nucleotide-excision repair by CBX2 expression — LUNG_SCLC

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