CBX1

Across TCGA pan-cancer cohorts, CBX1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CBX1 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CBX1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CBX1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, LSCC, and CCRCC are the cancer types where CBX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.910	0.613	.001	33	view →
LSCC	DFS	Median	II,III,IV	0.851	0.547	.003	20	view →
CCRCC	OS	Median	All	1.000	0.680	.016	18	view →
UCEC	OS	Quartile	II,III,IV	0.458	1.000	.009	8	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
OV	DFS	Median	All	0.860	1.000	.034	4	view →
PDAC	OS	Quartile	III,IV	1.000	0.362	.040	3	view →
GBM	OS	Quartile	All	0.592	0.289	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CBX1–LUAD (DFS)

Open the LUAD breakdown →