CBX1

Across TCGA patient cohorts, CBX1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBX1-associated genes across cancer lineages are 4E-BP1, EGFR_pY1068, and ERK2. Each is linked with CBX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBX1-to-partner and partner-to-CBX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CBX1-low versus CBX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX1→partner) and Y-score (partner→CBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.375	+3.584	<.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.249	-2.115	.008	.017	3	1
UCEC	ERK2 →	+0.176	+2.321	.014	.033	3	1
UCEC	FOXO3a_pS318_S321 →	-0.125	-2.000	.007	.029	3	1
UCEC	GSK-3_pS9 →	-0.396	-1.874	.009	.049	3	1
UCEC	JNK2 →	+0.219	+2.196	.003	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

4E-BP1 by CBX1 expression — UCEC

Explore this box plot interactively →