CBX1

Across TCGA cell cohorts, CBX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,417 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CBX1-associated GO terms across cancer lineages are Transcription initiation at RNA polymerase II promoter, Protein-DNA complex organization, and DNA-templated transcription initiation. Each is linked with CBX1 in more than 19 cancer types. Because this analysis shows association rather than direction, both CBX1-to-partner and partner-to-CBX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription initiation at RNA polymerase II promoter grouped by CBX1-low versus CBX1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX1→partner) and Y-score (partner→CBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Transcription initiation at RNA polymerase II promoter →	+0.066	+0.708	<.001	<.001	3	20
BONE	Protein-DNA complex organization →	+0.100	+0.751	<.001	.002	3	19
OESOPHAGUS	DNA-templated transcription initiation →	+0.059	+0.664	.004	.002	3	18
PANCREAS	DNA synthesis involved in DNA repair →	+0.110	+1.375	<.001	<.001	3	18
URINARY_TRACT	Regulation of cell cycle checkpoint →	+0.110	+0.901	.002	.004	3	17
BLOOD_Myeloma	Regulation of DNA-templated DNA replication initiation →	+0.156	+1.102	<.001	.004	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,417 associations by consensus.

Transcription initiation at RNA polymerase II promoter by CBX1 expression — OESOPHAGUS

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