CBWD2

Across TCGA pan-cancer cohorts, CBWD2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CBWD2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CBWD2 RNA is repressed in tumor relative to normal tissue. In most cancer types CBWD2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LIHC are the cancer types where CBWD2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CBWD2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−0.725	<.001	10	view →
KICH	Female	II,III,IV	−0.965	<.001	8	view →
LIHC	Female	All	+0.429	<.001	8	view →
HNSC	All	III,IV	+0.369	<.001	8	view →
BRCA	All	II,III,IV	+0.340	<.001	8	view →
STAD	All	II,III,IV	+0.584	<.001	6	view →
LUSC	All	All	+0.479	<.001	6	view →
COAD	All	All	+0.291	.001	6	view →
CHOL	All	II,III,IV	+1.695	<.001	5	view →
KIRP	Male	All	−0.410	<.001	4	view →
BLCA	All	All	+0.282	.009	3	view →
LUAD	All	All	+0.230	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CBWD2–THCA

Open the THCA breakdown →