CBS

Across TCGA cell cohorts, CBS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,206 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CBS-associated GO terms across cancer lineages are Hydrogen sulfide biosynthetic process, L-cysteine biosynthetic process, and Transsulfuration. Each is linked with CBS in more than 16 cancer types. Because this analysis shows association rather than direction, both CBS-to-partner and partner-to-CBS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Hydrogen sulfide biosynthetic process grouped by CBS-low versus CBS-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CBS→partner) and Y-score (partner→CBS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Hydrogen sulfide biosynthetic process →	+0.500	+2.023	.003	<.001	3	17
URINARY_TRACT	L-cysteine biosynthetic process →	+1.144	+2.471	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Transsulfuration →	+0.302	+2.904	<.001	<.001	3	17
LIVER	Sulfur amino acid biosynthetic process →	+0.168	+2.863	<.001	.002	3	16
KIDNEY	L-homocysteine catabolic process →	+0.248	+2.441	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Homocysteine metabolic process →	+0.158	+2.520	<.001	<.001	2	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,206 associations by consensus.

Hydrogen sulfide biosynthetic process by CBS expression — LUNG_SCLC

Explore this box plot interactively →