CBS

Across TCGA cell cohorts, CBS mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CBS-associated genes across cancer lineages are TSPAN16, KCNA4, and ASPN. Each is linked with CBS in more than 1 cancer types. Because this analysis shows association rather than direction, both CBS-to-partner and partner-to-CBS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPAN16 grouped by CBS-low versus CBS-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBS→partner) and Y-score (partner→CBS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TSPAN16 →	+0.042	+4.017	<.001	.007	3	1
OESOPHAGUS	KCNA4 →	+0.029	+4.017	.005	.007	3	1
LARGE_INTESTINE	ASPN →	+0.046	+3.841	<.001	<.001	3	1
LARGE_INTESTINE	NPM3 →	+0.679	+3.125	.007	.008	3	1
LARGE_INTESTINE	C18orf21 →	+0.812	+3.064	<.001	.009	3	1
LARGE_INTESTINE	FAM153CP →	+0.341	+3.561	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

TSPAN16 by CBS expression — OESOPHAGUS

Explore this box plot interactively →