CBR4

Across TCGA patient cohorts, CBR4 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBR4-associated genes across cancer lineages are Myosin-IIa_pS1943, STAT3_pY705, and TIGAR. Each is linked with CBR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBR4-to-partner and partner-to-CBR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by CBR4-low versus CBR4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBR4→partner) and Y-score (partner→CBR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.239	+2.183	.027	.035	3	1
UCEC	STAT3_pY705 →	-0.492	-2.990	<.001	.036	3	1
UCEC	TIGAR →	+0.160	+2.196	.045	.034	3	1
UCEC	XBP1 →	-0.290	-3.156	<.001	.018	3	1
UCEC	Bax →	+0.335	+2.817	.007	.036	3	1
UCEC	ERK2 →	+0.280	+3.000	.005	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Myosin-IIa_pS1943 by CBR4 expression — UCEC

Explore this box plot interactively →