CBR3

Across TCGA patient cohorts, CBR3 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBR3-associated genes across cancer lineages are TIGAR, Caspase-7-cleavedD198, and PCNA. Each is linked with CBR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBR3-to-partner and partner-to-CBR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by CBR3-low versus CBR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBR3→partner) and Y-score (partner→CBR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.155	+2.348	.043	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+0.725	+3.019	.015	.019	2	1
UCEC	PCNA →	+0.226	+3.459	.037	.005	1	1
UCEC	STAT3_pY705 →	-0.335	-2.321	.010	.035	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TIGAR by CBR3 expression — UCEC

Explore this box plot interactively →