CBR1

Across TCGA patient cohorts, CBR1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBR1-associated genes across cancer lineages are PCNA, EGFR_pY1068, and EGFR. Each is linked with CBR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBR1-to-partner and partner-to-CBR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CBR1-low versus CBR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBR1→partner) and Y-score (partner→CBR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.235	+2.700	.015	.006	3	2
UCEC	EGFR_pY1068 →	-0.305	-2.700	.006	.006	3	1
UCEC	EGFR →	-0.286	-3.143	<.001	.018	3	1
UCEC	eIF4E →	+0.199	+2.000	.036	.032	2	2
UCEC	A-Raf_pS299 →	-0.171	-2.584	.001	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.110	-2.449	.049	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

PCNA by CBR1 expression — UCEC

Explore this box plot interactively →