CBLN4

Across TCGA pan-cancer cohorts, CBLN4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CBLN4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CBLN4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CBLN4 is over-expressed in tumor, although a few such as UCEC and LUAD show the opposite, repressed pattern.

KIRC, UCEC, and THCA are the cancer types where CBLN4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CBLN4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.207	<.001	12	view →
UCEC	All	III,IV	−1.964	<.001	8	view →
THCA	Female	All	+0.911	<.001	7	view →
LUAD	All	II,III,IV	−0.617	.006	6	view →
LUSC	Male	II,III,IV	−1.125	<.001	5	view →
READ	All	II,III,IV	−0.092	<.001	5	view →
BRCA	Female	II,III,IV	−0.699	<.001	4	view →
LIHC	Male	All	+0.741	.011	2	view →
PRAD	All	All	−0.502	<.001	2	view →
HNSC	Male	All	−0.071	.025	2	view →
KICH	All	III,IV	−0.805	.038	1	view →
KIRP	All	All	−0.360	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CBLN4–KIRC

Open the KIRC breakdown →