CBLN1

Across TCGA patient cohorts, CBLN1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBLN1-associated genes across cancer lineages are Ku80, MEK1, and PDK1_pS241. Each is linked with CBLN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBLN1-to-partner and partner-to-CBLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by CBLN1-low versus CBLN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBLN1→partner) and Y-score (partner→CBLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.310	+3.335	.012	.005	3	1
UCEC	MEK1 →	+0.551	+3.169	.004	.019	3	1
UCEC	PDK1_pS241 →	+0.189	+2.183	.035	.035	3	1
UCEC	STAT3_pY705 →	-0.403	-2.999	.003	.035	3	1
UCEC	Tuberin_pT1462 →	+0.435	+2.817	<.001	.036	3	1
UCEC	Tuberin →	+0.466	+2.179	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Ku80 by CBLN1 expression — UCEC

Explore this box plot interactively →