CBLL2

Across TCGA pan-cancer cohorts, CBLL2 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated CBLL2 data layer compared with 6 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CBLL2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CBLL2 expression acts as an unfavorable survival marker, although some lineages such as ESCA and THYM show a favorable association.

ACC, KIRC, and CHOL are the cancer types where CBLL2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.116	0.706	<.001	93	view →
KIRC	DFS	Tertile	All	0.440	0.668	.001	72	view →
CHOL	DFS	Tertile	All	0.100	0.496	.006	63	view →
LGG	DFS	Tertile	All	0.232	0.427	<.001	36	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	36	view →
LUSC	OS	Tertile	II,III,IV	0.208	0.558	.020	30	view →
READ	OS	Tertile	IV	0.386	0.741	.037	18	view →
ESCA	OS	Median	III,IV	0.575	0.311	.017	18	view →
THYM	DFS	Quartile	All	1.000	0.826	.014	12	view →
LIHC	DFS	Tertile	II,III,IV	0.115	0.469	.016	9	view →
STAD	OS	Tertile	IV	0.642	0.203	.006	9	view →
KIRP	OS	Tertile	All	0.214	0.716	.012	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

CBLL2–ACC (OS)

Open the ACC breakdown →