CBLL1

Across TCGA pan-cancer cohorts, CBLL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CBLL1 data layer compared with 31 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CBLL1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CBLL1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where CBLL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.212	1.000	.014	31	view →
LSCC	DFS	Median	II,III,IV	0.847	0.543	.003	14	view →
PDAC	DFS	Tertile	III,IV	0.961	0.334	.019	8	view →
LUAD	DFS	Median	All	0.683	0.907	.036	4	view →
CCRCC	DFS	Median	IV	0.932	0.382	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CBLL1–HNSC (DFS)

Open the HNSC breakdown →