CBLL1

Across TCGA patient cohorts, CBLL1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBLL1-associated genes across cancer lineages are STAT5a, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with CBLL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBLL1-to-partner and partner-to-CBLL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT5a grouped by CBLL1-low versus CBLL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBLL1→partner) and Y-score (partner→CBLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT5a →	+0.336	+1.906	.036	.016	3	2
UCEC	EGFR_pY1068 →	-0.236	-2.807	.019	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.159	-2.459	.019	.019	3	1
UCEC	JNK2 →	+0.205	+2.415	.010	.003	3	1
UCEC	MEK1 →	+0.336	+2.459	.022	.019	3	1
UCEC	PDK1_pS241 →	+0.155	+2.807	.024	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

STAT5a by CBLL1 expression — UCEC

Explore this box plot interactively →