CBLL1

Across TCGA cell cohorts, CBLL1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CBLL1-associated genes across cancer lineages are MRO, MYBPC3, and OR5C1. Each is linked with CBLL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBLL1-to-partner and partner-to-CBLL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRO grouped by CBLL1-low versus CBLL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBLL1→partner) and Y-score (partner→CBLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MRO →	+0.321	+3.392	<.001	.006	3	1
LARGE_INTESTINE	MYBPC3 →	+0.035	+3.333	.001	.009	3	1
LARGE_INTESTINE	OR5C1 →	+0.031	+3.115	.003	.004	3	1
LARGE_INTESTINE	OR4F21 →	+0.133	+2.878	<.001	.009	3	1
BLOOD_Leukemia	PRAMEF9 →	+0.004	+4.969	<.001	.003	3	1
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MRO by CBLL1 expression — LARGE_INTESTINE

Explore this box plot interactively →