CBLL1

Across TCGA cell cohorts, CBLL1 mutation is significantly associated with the mutation status of many other genes, with 1,619 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CBLL1-associated genes across cancer lineages are NFX1, HUWE1, and MLF2. Each is linked with CBLL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBLL1-to-partner and partner-to-CBLL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NFX1 grouped by CBLL1-low versus CBLL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBLL1→partner) and Y-score (partner→CBLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NFX1 →	+2.630	+3.047	.005	.005	1	2
BLOOD_Leukemia	HUWE1 →	+2.572	+4.129	.009	.009	1	2
LARGE_INTESTINE	MLF2 →	+3.215	+3.415	.002	.002	1	2
LARGE_INTESTINE	COL5A3 →	+1.836	+2.906	.009	.009	1	2
LARGE_INTESTINE	ADAM22 →	+2.536	+3.504	.001	.001	1	2
LARGE_INTESTINE	HAL →	+3.215	+3.415	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,619 associations by consensus.

NFX1 by CBLL1 expression — LARGE_INTESTINE

Explore this box plot interactively →