CBLC

Across TCGA patient cohorts, CBLC protein abundance is significantly associated with the RNA expression of many other genes, with 4,644 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CBLC-associated genes across cancer lineages are FYN, DPYSL2, and PPM1H. Each is linked with CBLC in more than 2 cancer types. Because this analysis shows association rather than direction, both CBLC-to-partner and partner-to-CBLC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CBLC versus FYN in HNSC, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBLC→partner) and Y-score (partner→CBLC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FYN →	-0.701	-0.498	<.001	<.001	3	3
BRCA	DPYSL2 →	-0.844	-0.479	<.001	<.001	3	3
UCEC	PPM1H →	-1.067	-0.584	<.001	<.001	3	2
HNSC	MTERF2 →	-0.564	-0.705	<.001	<.001	3	2
HNSC	CHRNA1 →	-1.237	-0.380	<.001	.002	3	2
UCEC	SELENBP1 →	-1.359	-0.691	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,644 associations by consensus.

CBLC vs FYN — HNSC

Explore this scatter interactively →