CBLC

Across TCGA patient cohorts, CBLC mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBLC-associated genes across cancer lineages are EGFR_pY1068, Rad50, and STAT3_pY705. Each is linked with CBLC in more than 1 cancer types. Because this analysis shows association rather than direction, both CBLC-to-partner and partner-to-CBLC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CBLC-low versus CBLC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBLC→partner) and Y-score (partner→CBLC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.250	-2.321	.047	.035	3	1
UCEC	Rad50 →	-0.298	-3.459	.014	.005	3	1
UCEC	STAT3_pY705 →	-0.354	-3.459	.007	.005	3	1
UCEC	4E-BP1 →	+0.461	+3.029	<.001	.018	3	1
UCEC	p62 Lck ligand →	+0.504	+3.459	.002	.005	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

EGFR_pY1068 by CBLC expression — UCEC

Explore this box plot interactively →