CBLB

Across TCGA patient cohorts, CBLB mutation is significantly associated with the RNA expression of many other genes, with 6,571 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBLB-associated genes across cancer lineages are PEX12P1, H2AC12, and EOMES. Each is linked with CBLB in more than 2 cancer types. Because this analysis shows association rather than direction, both CBLB-to-partner and partner-to-CBLB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEX12P1 grouped by CBLB-low versus CBLB-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBLB→partner) and Y-score (partner→CBLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PEX12P1 →	+0.049	+4.920	<.001	<.001	3	3
UCEC	H2AC12 →	+0.490	+2.053	<.001	.001	3	3
UCEC	EOMES →	+0.520	+2.039	<.001	<.001	3	3
UCEC	CWF19L1 →	+0.278	+1.968	.001	.002	3	3
BRCA	PSAT1P4 →	+0.268	+3.424	<.001	.005	3	3
SKCM	DIPK2B →	-0.526	-2.150	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,571 associations by consensus.

PEX12P1 by CBLB expression — HNSC

Explore this box plot interactively →