CBLB

Across TCGA patient cohorts, CBLB mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBLB-associated genes across cancer lineages are PCNA, mTOR_pS2448, and ASNS. Each is linked with CBLB in more than 3 cancer types. Because this analysis shows association rather than direction, both CBLB-to-partner and partner-to-CBLB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CBLB-low versus CBLB-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBLB→partner) and Y-score (partner→CBLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PCNA →	+0.220	+2.179	.028	.035	3	4
UCEC	mTOR_pS2448 →	-0.101	-1.222	.016	.011	3	3
UCEC	ASNS →	+0.341	+1.807	<.001	.003	3	3
UCEC	Caspase-7-cleavedD198 →	+0.765	+1.784	<.001	<.001	3	3
LUSC	eEF2K →	+0.333	+2.179	.040	.035	3	2
UCEC	eIF4E →	+0.201	+2.237	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

PCNA by CBLB expression — LUSC

Explore this box plot interactively →