CBLB

Across TCGA cell cohorts, CBLB mutation is significantly associated with the RNA expression of many other genes, with 338 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CBLB-associated genes across cancer lineages are REG3G, EIF3L, and HSCB. Each is linked with CBLB in more than 1 cancer types. Because this analysis shows association rather than direction, both CBLB-to-partner and partner-to-CBLB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG3G grouped by CBLB-low versus CBLB-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBLB→partner) and Y-score (partner→CBLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	REG3G →	+0.044	+4.867	<.001	.009	3	2
LARGE_INTESTINE	EIF3L →	+0.513	+3.087	.002	.006	3	1
LARGE_INTESTINE	HSCB →	+0.542	+2.502	.003	.005	3	1
LARGE_INTESTINE	TOMM22 →	+0.507	+3.169	.001	.006	3	1
LARGE_INTESTINE	SLC25A17 →	+0.575	+2.502	.003	.005	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.498	+2.502	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 338 associations by consensus.

REG3G by CBLB expression — BLOOD_Lymphoma

Explore this box plot interactively →