CBL

Across TCGA patient cohorts, CBL mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBL-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and JNK2. Each is linked with CBL in more than 2 cancer types. Because this analysis shows association rather than direction, both CBL-to-partner and partner-to-CBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CBL-low versus CBL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBL→partner) and Y-score (partner→CBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.337	+1.097	.045	.048	3	3
UCEC	eEF2 →	+0.213	+1.502	.036	.025	3	2
UCEC	JNK2 →	+0.242	+1.584	<.001	.001	3	2
UCEC	P-Cadherin →	-0.093	-2.321	.023	.005	3	2
UCEC	Shc_pY317 →	-0.119	-1.392	.006	.017	3	2
UCEC	ASNS →	+0.227	+1.152	.027	.048	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Caspase-7-cleavedD198 by CBL expression — UCEC

Explore this box plot interactively →