CBL

Across TCGA cell cohorts, CBL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,650 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CBL-associated GO terms across cancer lineages are Microtubule cytoskeleton organization involved in mitosis, Microtubule organizing center organization, and Centrosome duplication. Each is linked with CBL in more than 17 cancer types. Because this analysis shows association rather than direction, both CBL-to-partner and partner-to-CBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule cytoskeleton organization involved in mitosis grouped by CBL-low versus CBL-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CBL→partner) and Y-score (partner→CBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Microtubule cytoskeleton organization involved in mitosis →	+0.096	+0.918	.007	.004	3	18
LUNG_NSCLC_LUSC	Microtubule organizing center organization →	+0.089	+1.158	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Centrosome duplication →	+0.098	+0.960	<.001	<.001	3	18
LIVER	Protein monoubiquitination →	+0.098	+0.978	<.001	.001	3	18
KIDNEY	Positive regulation of cell cycle →	+0.064	+0.748	.001	.006	3	17
KIDNEY	Mitotic sister chromatid segregation →	+0.085	+0.842	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,650 associations by consensus.

Microtubule cytoskeleton organization involved in mitosis by CBL expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →