CBL

Across TCGA cell cohorts, CBL mutation is significantly associated with the mutation status of many other genes, with 5,788 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CBL-associated genes across cancer lineages are PCDHA4, ZNF268, and NID1. Each is linked with CBL in more than 4 cancer types. Because this analysis shows association rather than direction, both CBL-to-partner and partner-to-CBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDHA4 grouped by CBL-low versus CBL-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBL→partner) and Y-score (partner→CBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PCDHA4 →	+3.000	+3.662	.007	.007	1	5
SKIN	ZNF268 →	+4.239	+5.053	.007	.007	1	4
BLOOD_Leukemia	NID1 →	+3.050	+3.247	.008	.008	1	4
SKIN	ZNF467 →	+4.239	+5.053	.007	.007	1	4
LARGE_INTESTINE	MYBPC1 →	+3.222	+2.893	.003	.003	1	4
LUNG_NSCLC_LUAD	ESF1 →	+5.000	+4.187	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,788 associations by consensus.

PCDHA4 by CBL expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →