CBFA2T2

Across TCGA patient cohorts, CBFA2T2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBFA2T2-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and HSP70. Each is linked with CBFA2T2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBFA2T2-to-partner and partner-to-CBFA2T2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CBFA2T2-low versus CBFA2T2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBFA2T2→partner) and Y-score (partner→CBFA2T2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.187	+2.824	.002	.034	3	2
UCEC	MEK1 →	+0.377	+3.321	.007	.009	3	2
SKCM	HSP70 →	-0.639	-3.000	.034	.036	3	1
SKCM	LKB1 →	-0.159	-3.000	.016	.036	3	1
COAD	GSK3-a-b →	+0.182	+3.212	.015	.009	3	1
COAD	Paxillin →	-0.408	-3.161	.019	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Caspase-7-cleavedD198 by CBFA2T2 expression — COAD

Explore this box plot interactively →