CBFA2T2

Across TCGA cell cohorts, CBFA2T2 mutation is significantly associated with the RNA expression of many other genes, with 504 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CBFA2T2-associated genes across cancer lineages are HMGXB4, EP300, and CRNKL1. Each is linked with CBFA2T2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBFA2T2-to-partner and partner-to-CBFA2T2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGXB4 grouped by CBFA2T2-low versus CBFA2T2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBFA2T2→partner) and Y-score (partner→CBFA2T2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HMGXB4 →	+0.646	+3.169	<.001	.005	3	1
LARGE_INTESTINE	EP300 →	+0.968	+3.502	<.001	.001	3	1
LARGE_INTESTINE	CRNKL1 →	+0.502	+3.389	.001	.001	3	1
LARGE_INTESTINE	R3HCC1 →	+0.745	+3.502	.002	.001	3	1
LARGE_INTESTINE	SF3A2 →	+0.582	+3.067	<.001	.009	3	1
LARGE_INTESTINE	TIMM44 →	+0.601	+3.169	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 504 associations by consensus.

HMGXB4 by CBFA2T2 expression — LARGE_INTESTINE

Explore this box plot interactively →